Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873079 | 0.84 | TPH1 (0.83) | TPH1 | |
| SCHEMBL1129389 | 0.84 | TPH1 (0.70) | TPH1 | |
| SCHEMBL2237775 | 0.84 | TPH1 (0.70) | TPH1 | |
| SCHEMBL870567 | 0.83 | TPH1 (0.74) | TPH1 | |
| SCHEMBL870566 | 0.83 | TPH1 (0.74) | TPH1 | |
| SCHEMBL1768158 | 0.79 | TPH1 (0.55) | TPH1 | |
| SCHEMBL1880944 | 0.78 | TPH1 (0.55) | TPH1 | |
| SCHEMBL1129126 | 0.78 | TPH1 (0.55) | TPH1 | |
| SCHEMBL1870002 | 0.77 | TPH1 (0.68) | TPH1 | |
| SCHEMBL1872988 | 0.76 | TPH1 (0.70) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009522265-A | — | — | 2009-06-11 | — | — | JP | claimed |
| EP-1984344-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007089335-A2 | MULTICYCLIC AMINO ACID DERIVATIVES AND METHODS OF THEIR USE | LEXICON PHARMACEUTICAL INC. (US) | 2007-08-09 | — | — | WO | claimed |
| WO-2014082034-A1 | METHODS FOR TREATING IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2014-05-30 | — | — | WO | disclosed |
| EP-2504008-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | Lexicon Pharmaceuticals, Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063181-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. (US) | 2011-05-26 | — | — | WO | disclosed |