Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129389 | 1.00 | TPH1 (0.70) | TPH1HRH4 | |
| SCHEMBL1768158 | 0.87 | TPH1 (0.55) | TPH1 | |
| SCHEMBL1768161 | 0.84 | TPH1 (0.62) | TPH1 | |
| SCHEMBL307738 | 0.83 | TPH1 (1.00) | TPH1 | |
| SCHEMBL308216 | 0.83 | TPH1 (1.00) | TPH1 | |
| SCHEMBL307739 | 0.83 | TPH1 (1.00) | TPH1 | |
| SCHEMBL1873079 | 0.82 | TPH1 (0.83) | TPH1 | |
| SCHEMBL1768172 | 0.81 | TPH1 (0.53) | TPH1HRH4 | |
| SCHEMBL1768131 | 0.80 | TPH1 (0.68) | TPH1 | |
| SCHEMBL12159891 | 0.79 | TPH1 (0.62) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533778-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE | Lexicon Pharmaceuticals, Inc. (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100285-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF METASTATIC BONE DISEASE | LEXICON PHARMACEUTICALS, INC. (US) | 2011-08-18 | — | — | WO | disclosed |
| WO-2010062829-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR TREATING OSTEOPOROSIS | LEXICON PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | WO | disclosed |
| EP-2178536-A1 | METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-28 | — | — | EP | disclosed |
| EP-2170306-A1 | METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-2170397-A1 | METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION AND RELATED DISEASES AND DISORDERS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-2170335-A1 | COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS | Lexicon Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009014972-A1 | METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN | LEXICON PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009009561-A1 | METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION AND RELATED DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009002964-A1 | METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009002970-A1 | COMPOSITIONS COMPRISING TRYPTOPHAN HYDROXYLASE INHIBITORS | LEXICON PHARMACEUTICALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |