Glycyrrhizin

Glycyrrhizin

SCHEMBL17684

CC1(C)[C@@H](O[C@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 12/20 1.00
HSD11B2 P80365 11/20 1.00
SLCO1B3 Q9NPD5 2/20 1.00
SLCO1B1 Q9Y6L6 2/20 1.00
HMGB1 P09429 1/20 1.00
LMNA P02545 2/20 0.71
CES2 O00748 3/20 0.65
CES1 P23141 3/20 0.65
HSD17B1 P14061 1/20 0.65
HSD17B2 P37059 1/20 0.65
PTPN1 P18031 4/20 0.63
CYP3A4 P08684 2/20 0.63
MAPT P10636 2/20 0.63
MEN1 O00255 1/20 0.63
AKR1B10 O60218 1/20 0.63
ALOX5 P09917 1/20 0.63
PRKCH P24723 1/20 0.63
PTPN6 P29350 1/20 0.63
KMT2A Q03164 1/20 0.63
PTPN11 Q06124 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycyrrhizin SCHEMBL15833919 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL7688850 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL17880405 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL21424347 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL24626512 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL11007323 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL23309804 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL13294344 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL23747025 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL22200125 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 70001 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746844-A1 PERSONAL CARE COMPOSITIONS Colgate-Palmolive Company (US) 2026-05-27 EP claimed
CN-122075342-A Composition, and preparation method and application thereof 2026-05-26 CN claimed
CN-122080107-A Method for green extraction of glycyrrhizic acid 2026-05-26 CN claimed
CN-117327135-B Method for increasing leaching of saccharides and glycoside components and application thereof INSTITUTE OF CHINESE MATERIA MEDICA, CHINA ACADEMY OF CHINESE MEDICAL SCIENCES (CN) 2026-05-26 CN claimed
US-12636251-B1 Glycoside-containing aqueous formulations having a lipophilic active component Doane Technology Group LLC (US) 2026-05-26 US claimed
CN-122075319-A Composition, and preparation method and application thereof 2026-05-26 CN claimed
CN-122075589-A Preparation method of pelvic inflammation eliminating oral liquid 2026-05-26 CN claimed
CN-121081676-B Middle internal phase Pickering emulsion gel and preparation method and application thereof Wenzhou Research Institute of Guoke (Wenzhou Institute of biomaterials and Engineering) (CN) 2026-05-26 CN claimed
CN-118542924-B Multifunctional traditional Chinese medicine composition, oral preparation, and preparation methods and applications thereof GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE (GUANGZHOU INSTITUTE OF TRADITIONAL CHINESE MEDICINE) (CN) 2026-05-26 CN claimed
CN-122072266-A Detection method of traditional Chinese medicine composition for treating lung heat cough and asthma 贵州三力制药股份有限公司 2026-05-22 CN claimed
US-4241091-A HIGHER VOLUME LIFE SAVERS, INC. (US) 1980-12-23 US claimed
US-4238475-A HYDROCOLLOID COATINGS OF THERAPEUTIC PARTICLES DISPERSED IN THE GUM LIFE SAVERS INC. (US) 1980-12-09 US claimed
US-4217368-A Long-lasting chewing gum and method LIFE SAVERS, INC. (US) 1980-08-12 US claimed
US-4208431-A SWEETENER, SOFTENER LIFE SAVERS, INC. (US) 1980-06-17 US claimed
US-4191781-A AMMONIATED GLYCYRRHIZIN GENERAL FOODS CORPORATION (US) 1980-03-04 US claimed
US-4181712-A DETERGENTS, SILICA GEL, CHARCOAL RIALDI GIORGIO 1980-01-01 US claimed
US-4176201-A Sweetening composition MACANDREWS AND FORBES COMPANY (US) 1979-11-27 US claimed
US-4176228-A Potassium-magnesium-calcium glycyrrhizin MACANDREWS AND FORBES COMPANY (US) 1979-11-27 US claimed
US-4127645-A CANDY, LEAVENING AGENT AND AN ACIDULANT LIFE SAVERS, INC. (US) 1978-11-28 US claimed
US-3953423-A Preparation of a new flavanone derivative H. TROMMSDORFF (DT) 1976-04-27 US claimed