Glycyrrhizin

Glycyrrhizin

SCHEMBL22200125

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nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 12/20 1.00
HSD11B2 P80365 11/20 1.00
SLCO1B3 Q9NPD5 2/20 1.00
SLCO1B1 Q9Y6L6 2/20 1.00
HMGB1 P09429 1/20 1.00
LMNA P02545 2/20 0.71
CES2 O00748 3/20 0.65
CES1 P23141 3/20 0.65
HSD17B1 P14061 1/20 0.65
HSD17B2 P37059 1/20 0.65
PTPN1 P18031 4/20 0.63
CYP3A4 P08684 2/20 0.63
MAPT P10636 2/20 0.63
MEN1 O00255 1/20 0.63
AKR1B10 O60218 1/20 0.63
ALOX5 P09917 1/20 0.63
PRKCH P24723 1/20 0.63
PTPN6 P29350 1/20 0.63
KMT2A Q03164 1/20 0.63
PTPN11 Q06124 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycyrrhizin SCHEMBL15833919 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL7688850 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL17880405 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL21424347 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL24626512 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL11007323 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL23309804 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL13294344 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL23747025 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1
Glycyrrhizin SCHEMBL14514292 1.00 HSD11B1 (1.00) HSD11B1HSD11B2SLCO1B3SLCO1B1HMGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210876-A1 PHARMACEUTICAL COMPOSITION CONTAINING PENTACYCLIC TRITERPENOIDS SPV TIMSER, S.A.P.I. DE C.V. (MX) 2023-07-06 US disclosed
US-20220168230-A1 NANOPARTICLE MEDIATED THERAPY YALE UNIVERSITY 2022-06-02 US disclosed
WO-2021074158-A1 ORAL CARE COMPOSITION LACER, S.A. (ES) 2021-04-22 WO disclosed
WO-2021074164-A1 ORAL CARE COMPOSITON LACER, S.A. (ES) 2021-04-22 WO disclosed
EP-3808327-A1 ORAL CARE COMPOSITON Lacer, S.A. (ES) 2021-04-21 EP disclosed
US-20200214989-A1 NANOMATERIALS WITH ENHANCED DRUG DELIVERY EFFICIENCY YALE UNIVERSITY 2020-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210876-A1 PHARMACEUTICAL COMPOSITION CONTAINING PENTACYCLIC TRITERPENOIDS CYP11B2, CYP4A11, CYP11B1 HSD11B1 8/4885HSD11B2 13/4885SLCO1B3 1641/4885
US-20200214989-A1 NANOMATERIALS WITH ENHANCED DRUG DELIVERY EFFICIENCY VIP, SI, LSS HSD11B1 298/4885HSD11B2 439/4885SLCO1B3 1079/4885
US-20220168230-A1 NANOPARTICLE MEDIATED THERAPY LSS, CYP46A1, CYP51A1 HSD11B1 36/4885HSD11B2 190/4885SLCO1B3 3252/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.