Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 4/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741957 | 0.92 | ARG1 (0.39) | FPR2CASRCXCR4 | |
| SCHEMBL1741950 | 0.92 | ARG1 (0.39) | FPR2CASRCXCR4 | |
| SCHEMBL15501036 | 0.92 | ARG1 (0.39) | FPR2CASRCXCR4 | |
| SCHEMBL17685156 | 0.90 | CASR (0.31) | FPR2CASR | |
| SCHEMBL2834770 | 0.86 | TBXAS1 (0.31) | FPR2CASRCXCR4 | |
| SCHEMBL1741937 | 0.82 | ARG1 (0.43) | FPR2CXCR4 | |
| SCHEMBL1741941 | 0.82 | ARG1 (0.43) | FPR2CXCR4 | |
| SCHEMBL11937134 | 0.81 | FPR2 (0.34) | FPR2 | |
| SCHEMBL17690537 | 0.80 | FPR2 (0.36) | FPR2CXCR4 | |
| SCHEMBL16374660 | 0.80 | CXCR4 (0.33) | CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2706057-B1 | Bis(imidazolyl)compounds and radionuclide complexes | MOLECULAR INSIGHT PHARM INC (US) | 2016-04-20 | — | — | EP | claimed |