Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144361 | 0.88 | KDM4E (0.50) | KDM4EMAPTALDH1A1LMNACNR2 | |
| SCHEMBL14087963 | 0.67 | KDM4E (0.52) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL921576 | 0.67 | L3MBTL1 (0.54) | KDM4ELMNAKMT2AMEN1RAB9A | |
| SCHEMBL30485981 | 0.65 | RAB9A (0.68) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL126159 | 0.65 | RAB9A (0.68) | MAPTKMT2AMEN1RAB9ANPC1 | |
| SCHEMBL31038670 | 0.64 | ALDH1A1 (0.54) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL247331 | 0.64 | ALDH1A1 (0.54) | MAPTALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7478159 | 0.63 | MAP3K5 (0.45) | MAPTLMNAKMT2AMEN1RAB9A | |
| SCHEMBL5833360 | 0.63 | HPGD (0.50) | KDM4EMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL6027438 | 0.62 | ADORA1 (0.54) | CNR2RAB9ACYP2C19SMN1; SMN2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |