Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328239 | 0.84 | MAPT (0.47) | SMN1; SMN2GAAALOX12ALDH1A1HTT | |
| SCHEMBL22179473 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2KHKALDH1A1HTTMAPT | |
| SCHEMBL20121672 | 0.77 | L3MBTL3 (0.53) | ADRB1SMN1; SMN2KHKALDH1A1MAPT | |
| SCHEMBL22174801 | 0.76 | L3MBTL1 (0.58) | ADRB1SMN1; SMN2GAAKHKALDH1A1 | |
| SCHEMBL10126824 | 0.75 | ALDH1A1 (0.69) | GAAALDH1A1HTTMAPTKMT2A | |
| SCHEMBL15728450 | 0.74 | HRH3 (0.42) | KHKKMT2AMEN1 | |
| SCHEMBL3341828 | 0.73 | ALDH1A1 (0.70) | SMN1; SMN2GAAALDH1A1HTTMAPT | |
| SCHEMBL10035939 | 0.73 | MAPT (0.56) | GAAALDH1A1HTTMAPTKMT2A | |
| SCHEMBL6128525 | 0.72 | MAPT (0.69) | ADRB1GAAALDH1A1MAPTKMT2A | |
| SCHEMBL6052282 | 0.72 | MAPT (0.55) | SMN1; SMN2GAAALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B9 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-20 | — | — | EP | disclosed |