Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.48 |
| ▸ | MERTK | Q12866 | 3/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 6/20 | 0.47 |
| ▸ | ROS1 | P08922 | 6/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | CCND3 | P30281 | 2/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129237 | 0.88 | RET (0.55) | FLT3RETROS1EML4ALK | |
| SCHEMBL17690593 | 0.79 | SYK (0.50) | FLT3RETROS1EML4ALK | |
| SCHEMBL10129377 | 0.78 | ALK (0.77) | FLT3RETROS1EML4ALK | |
| SCHEMBL10129473 | 0.77 | EML4 (0.61) | FLT3RETROS1EML4ALK | |
| SCHEMBL10129427 | 0.76 | EML4 (0.59) | FLT3RETROS1EML4ALK | |
| SCHEMBL10129238 | 0.75 | EML4 (0.61) | FLT3RETROS1EML4ALK | |
| SCHEMBL16541266 | 0.75 | EML4 (0.70) | FLT3RETROS1EML4ALK | |
| SCHEMBL10157453 | 0.74 | EML4 (0.61) | FLT3RETROS1EML4ALK | |
| SCHEMBL17690651 | 0.72 | ALK (0.64) | FLT3RETROS1EML4ALK | |
| SCHEMBL10157513 | 0.72 | EML4 (0.53) | FLT3MERTKTYRO3GAS6RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B9 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-20 | — | — | EP | disclosed |