Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.50 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | CCND3 | P30281 | 2/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129237 | 0.91 | RET (0.55) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL14956008 | 0.82 | SYK (0.65) | SYKRETROS1FLT3EML4 | |
| SCHEMBL10127393 | 0.81 | CCND3 (0.56) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL17689779 | 0.79 | FLT3 (0.48) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL16206874 | 0.79 | BTK (0.55) | SYKLCKJAK3EML4ALK | |
| SCHEMBL24927490 | 0.79 | LCK (0.59) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL21946318 | 0.79 | LCK (0.59) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL21855164 | 0.79 | LCK (0.59) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL31039906 | 0.79 | LCK (0.59) | SYKLCKJAK3CCND3CCNK | |
| SCHEMBL16541266 | 0.78 | EML4 (0.70) | SYKLCKJAK3RETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009428-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |