Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.46 |
| ▸ | JAK3 | P52333 | 7/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144688 | 0.86 | JAK1 (0.56) | JAK2JAK3JAK1PTK2POLB | |
| SCHEMBL13392633 | 0.82 | JAK2 (0.57) | JAK2JAK3JAK1PTK2LRRK2 | |
| SCHEMBL2144112 | 0.80 | ALDH1A1 (0.49) | JAK2JAK3JAK1PTK2 | |
| SCHEMBL3303500 | 0.77 | KCNH3 (0.53) | JAK2JAK3PTK2LRRK2ALOX15 | |
| SCHEMBL3300093 | 0.75 | JAK2 (0.47) | JAK2JAK3PTK2TDP1 | |
| SCHEMBL2144480 | 0.74 | JAK2 (0.64) | JAK2JAK3JAK1PTK2 | |
| SCHEMBL2144285 | 0.72 | PTGS2 (0.50) | JAK2JAK3JAK1PTK2TDP1 | |
| SCHEMBL2790709 | 0.72 | JAK2 (0.55) | JAK2JAK3JAK1PTK2LRRK2 | |
| SCHEMBL3266110 | 0.72 | JAK2 (0.55) | JAK2JAK3JAK1PTK2LRRK2 | |
| SCHEMBL2145235 | 0.72 | MAPK8 (0.43) | JAK2JAK3JAK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |