Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 6/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL771296 | 0.92 | GNAI3 (0.47) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL770942 | 0.86 | GNAI3 (0.49) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL771290 | 0.83 | LMNA (0.41) | GNAI3GNAO1GNAI1POLBHSD11B1 | |
| SCHEMBL770787 | 0.82 | GNAI3 (0.46) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL771655 | 0.81 | HSD11B1 (0.51) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL771054 | 0.81 | LMNA (0.39) | GNAI3GNAO1GNAI1HSD11B1 | |
| SCHEMBL770911 | 0.77 | POLB (0.52) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL770938 | 0.76 | NPC1 (0.59) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL771899 | 0.75 | ATM (0.47) | GNAI3GNAO1GNAI1POLBMEN1 | |
| SCHEMBL770695 | 0.75 | HSD11B1 (0.46) | GNAI3GNAO1GNAI1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439202-B1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | SALVAT LAB SA (ES) | 2016-04-20 | — | — | EP | disclosed |