Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769255 | 0.90 | KDM4E (0.44) | KDM4EALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL1769102 | 0.81 | HTT (0.41) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL1769028 | 0.81 | MET (0.42) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL1768881 | 0.79 | ADORA1 (0.40) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL1769127 | 0.70 | ADORA2A (0.46) | KDM4EALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL14956448 | 0.65 | MET (0.46) | KDM4EALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL14970033 | 0.65 | MET (0.46) | KDM4EALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL6437228 | 0.63 | MET (0.42) | KDM4EALDH1A1MAPTHPGDGAA | |
| SCHEMBL6251718 | 0.62 | KDM4E (1.00) | KDM4EALDH1A1MAPTMAPK1HSD17B10 | |
| Hydrochloric Acid SCHEMBL23013699 | 0.62 | MET (0.41) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501700-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061157-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-26 | — | — | WO | disclosed |