Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HPGD | P15428 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | PKM | P14618 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769028 | 0.83 | MET (0.42) | HTTLMNAPOLBSMN1; SMN2MET | |
| SCHEMBL1769116 | 0.81 | KDM4E (0.46) | HTTSMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL1769255 | 0.78 | KDM4E (0.44) | HTTLMNAPOLBHIF1AMET | |
| SCHEMBL6437228 | 0.65 | MET (0.42) | POLBMETMAPTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL23013699 | 0.64 | MET (0.41) | METADORA2A | |
| SCHEMBL12649852 | 0.63 | MET (0.50) | HTTLMNAPOLBSMN1; SMN2MET | |
| SCHEMBL8269242 | 0.63 | MET (0.44) | METKDM4EMEN1KMT2A | |
| SCHEMBL1584535 | 0.62 | HTT (0.39) | HTTLMNAPOLBNCOA1SMN1; SMN2 | |
| SCHEMBL16355263 | 0.62 | LMNA (0.40) | HTTLMNAPOLBNCOA1SMN1; SMN2 | |
| SCHEMBL12649578 | 0.60 | MET (0.52) | HTTLMNAPOLBSMN1; SMN2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501700-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061157-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-26 | — | — | WO | disclosed |