Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.34 |
| ▸ | HPGD | P15428 | 8/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | MEN1 | O00255 | 7/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.34 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | GLA | P06280 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.33 |
| ▸ | PKM | P14618 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769102 | 0.83 | HTT (0.41) | METADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL1769116 | 0.81 | KDM4E (0.46) | ADORA2AADORA2BADORA1ALDH1A1KDM4E | |
| SCHEMBL1769186 | 0.79 | ALDH1A1 (0.40) | METADORA2AADORA1ALDH1A1KDM4E | |
| SCHEMBL1769255 | 0.78 | KDM4E (0.44) | METADORA2AADORA1ALDH1A1KDM4E | |
| SCHEMBL6437228 | 0.65 | MET (0.42) | METADORA2AALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL23013699 | 0.64 | MET (0.41) | METADORA2A | |
| SCHEMBL12649904 | 0.63 | MET (0.55) | METALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8269242 | 0.63 | MET (0.44) | METKDM4EMEN1KMT2A | |
| SCHEMBL12649853 | 0.62 | MET (0.54) | MET | |
| SCHEMBL17342570 | 0.62 | ADORA1 (0.35) | ADORA2AADORA1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501700-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061157-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-26 | — | — | WO | disclosed |