Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768941 | 0.92 | ALDH1A1 (0.45) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1769305 | 0.87 | MET (0.41) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1768881 | 0.85 | ADORA1 (0.40) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1769127 | 0.83 | ADORA2A (0.46) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1769028 | 0.79 | MET (0.42) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL14970100 | 0.69 | MET (0.47) | ALDH1A1METKDM4EHPGDHTT | |
| SCHEMBL14956578 | 0.69 | MET (0.47) | ALDH1A1METKDM4EHPGDHTT | |
| SCHEMBL12649672 | 0.69 | MET (0.46) | ALDH1A1METKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL12649850 | 0.69 | MET (0.49) | ALDH1A1METKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1769014 | 0.68 | MET (0.41) | ALDH1A1METKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501700-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Bayer Intellectual Property GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061157-A1 | FUROPYRIDINYL-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-26 | — | — | WO | disclosed |