Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | NRAS | P01111 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17697688 | 0.81 | MAP3K14 (0.41) | TNFEIF2AK4FLT3TGFBR1CDK7 | |
| SCHEMBL17697727 | 0.78 | RIPK2 (0.38) | TNFIRAK4PRMT5WDR77TGFBR1 | |
| SCHEMBL17697709 | 0.76 | CYP1A2 (0.44) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL30977360 | 0.75 | KDR (0.40) | TNFNPC1RAB9AFLT3PRMT5 | |
| SCHEMBL792707 | 0.74 | ADORA3 (0.44) | NPC1RAB9AFLT3 | |
| SCHEMBL28041698 | 0.74 | POLB (0.54) | POLBNPC1RAB9AEIF2AK4MEN1 | |
| SCHEMBL17697685 | 0.73 | MET (0.60) | FLT3NRAS | |
| SCHEMBL3325146 | 0.71 | POLB (0.51) | POLBNPC1RAB9AEIF2AK4MEN1 | |
| SCHEMBL16404632 | 0.71 | POLB (0.56) | POLBNPC1RAB9AEIF2AK4MEN1 | |
| SCHEMBL3020269 | 0.71 | POLB (0.51) | POLBNPC1RAB9AEIF2AK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3012259-B1 | FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2020-06-03 | — | — | EP | disclosed |
| US-9988381-B2 | Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-06-05 | — | — | US | disclosed |
| US-20160137640-A1 | FIVE-MEMBER-HETEROCYCLE FUSED PYRIDINE COMPOUNDS, METHOD OF PRODUCING THE SAME, AND USE THEREOF | SHANGHAI HAIHE PHARMACEUTICAL CO. LTD. (CN) | 2016-05-19 | — | — | US | disclosed |
| EP-3012259-A1 | FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2016-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137640-A1 | FIVE-MEMBER-HETEROCYCLE FUSED PYRIDINE COMPOUNDS, METHOD OF PRODUCING THE SAME, AND USE THEREOF | ABL1, JAK2, LCK | POLB 4761/4885TNF 1549/4885NPC1 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.