Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 12/20 | 0.54 |
| ▸ | PPARG | P37231 | 5/20 | 0.53 |
| ▸ | PPARA | Q07869 | 4/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17698020 | 0.76 | NR1H4 (0.57) | NR1H4PPARGPPARAKCNK9TP53 | |
| SCHEMBL7297239 | 0.73 | NR1H4 (0.81) | NR1H4KCNK9SMN1; SMN2HDAC3HDAC11 | |
| SCHEMBL3873116 | 0.73 | NR1H4 (0.81) | NR1H4KCNK9SMN1; SMN2HDAC3HDAC11 | |
| SCHEMBL7303163 | 0.72 | HDAC3 (0.86) | NR1H4MAPTSMN1; SMN2HDAC3HDAC11 | |
| SCHEMBL5697470 | 0.71 | NR1H4 (0.68) | NR1H4TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL9696412 | 0.71 | NR1H4 (0.77) | NR1H4PPARGPPARAKCNK9TP53 | |
| SCHEMBL4611487 | 0.70 | HDAC3 (0.71) | NR1H4TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL3882727 | 0.70 | HDAC3 (0.71) | NR1H4TP53MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL557111 | 0.70 | HDAC6 (0.71) | NR1H4KCNK9TP53MAPTSMN1; SMN2 | |
| SCHEMBL7301440 | 0.70 | SMN1; SMN2 (0.78) | NR1H4TP53MAPTSMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716285-B9 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT DE LA RECH SCIENT -CNRS- (FR) | 2017-03-01 | — | — | EP | claimed |
| EP-2716285-B1 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT RECH SCIENT (FR) | 2016-04-27 | — | — | EP | claimed |