Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 5/20 | 0.42 |
| ▸ | ORAI3 | Q9BRQ5 | 5/20 | 0.42 |
| ▸ | TRPV6 | Q9H1D0 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138689 | 0.89 | CYP3A4 (0.46) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL12270711 | 0.85 | ORAI1 (0.61) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL3275709 | 0.85 | ORAI1 (0.38) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL1138415 | 0.84 | ORAI1 (0.43) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL5166435 | 0.84 | TRPV6 (0.57) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL2404895 | 0.81 | ORAI1 (0.41) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL12270552 | 0.79 | S1PR1 (0.40) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL12266156 | 0.79 | LPL (0.48) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL1005817 | 0.78 | — | — | |
| SCHEMBL13476001 | 0.77 | ORAI1 (0.41) | ORAI1ORAI2ORAI3TRPV6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1961756-B1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE & TECH AGENCY (JP) | 2016-04-27 | — | — | EP | claimed |