Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.41 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138689 | 0.87 | CYP3A4 (0.46) | ORAI1ORAI2ORAI3TRPV6CA2 | |
| SCHEMBL12270711 | 0.84 | ORAI1 (0.61) | ORAI1ORAI2ORAI3TRPV6CA2 | |
| SCHEMBL257894 | 0.83 | CA2 (0.52) | CA1CA2HTR2ASLC6A4KCNH2 | |
| SCHEMBL5166435 | 0.82 | TRPV6 (0.57) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL1138415 | 0.82 | ORAI1 (0.43) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL17698482 | 0.81 | ORAI1 (0.42) | ORAI1ORAI2ORAI3TRPV6CA2 | |
| SCHEMBL2407446 | 0.80 | ORAI1 (0.38) | ORAI1ORAI2ORAI3TRPV6CA1 | |
| SCHEMBL3275771 | 0.79 | ORAI1 (0.37) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL12270552 | 0.78 | S1PR1 (0.40) | ORAI1ORAI2ORAI3TRPV6CYP3A4 | |
| SCHEMBL12266156 | 0.78 | LPL (0.48) | ORAI1ORAI2ORAI3TRPV6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853424-B2 | Protein cross-linking inhibitor | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | BAZ2B, PRMT1, BRIX1 | ORAI1 4605/4885ORAI2 3906/4885ORAI3 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.