Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5352100 | 0.83 | ALDH1A1 (0.46) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL6553652 | 0.81 | GPR3 (0.33) | LMNA | |
| Hydrochloric Acid SCHEMBL29565043 | 0.80 | CYP19A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL687758 | 0.80 | CYP19A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL8857238 | 0.79 | ALDH1A1 (0.35) | NPC1ALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL17698617 | 0.78 | CA12 (0.33) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL17698566 | 0.77 | CYP1A2 (0.38) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| Ethylene SCHEMBL5512109 | 0.76 | CYP19A1 (0.30) | — | |
| Fluoride Ion SCHEMBL1131352 | 0.76 | — | — | |
| Bromide SCHEMBL2526728 | 0.76 | HTR2A (0.32) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473323-B1 | Polyethylene composition and process for producing same | TOSOH CORP (JP) | 2016-04-27 | — | — | EP | disclosed |