Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3685212 | 0.86 | ALDH1A1 (0.33) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL7272244 | 0.81 | ELANE (0.36) | ALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3683429 | 0.81 | NPC1 (0.36) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Ethane SCHEMBL8540098 | 0.80 | CYP2D6 (0.33) | NFKB1 | |
| Hydrochloric Acid SCHEMBL5345635 | 0.80 | ALDH1A1 (0.46) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL673540 | 0.80 | CYP2D6 (0.35) | NFKB1 | |
| Hydrochloric Acid SCHEMBL2479388 | 0.80 | CYP1A2 (0.38) | — | |
| Methane SCHEMBL6558661 | 0.78 | CYP2D6 (0.34) | — | |
| Hydrochloric Acid SCHEMBL5349951 | 0.78 | ALDH1A1 (0.40) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL8857238 | 0.76 | ALDH1A1 (0.35) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473323-B1 | Polyethylene composition and process for producing same | TOSOH CORP (JP) | 2016-04-27 | — | — | EP | disclosed |