SCHEMBL17698628

SCHEMBL17698628

CCc1ccccc1-n1c2c(c3ccccc31)CN(C)CC2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.59
CYP2D6 P10635 2/20 0.59
MAOA P21397 4/20 0.58
MAOB P27338 4/20 0.58
HTR1A P08908 2/20 0.55
ADRA2A P08913 2/20 0.55
CHRM1 P11229 2/20 0.55
SLC6A4 P31645 2/20 0.55
ADRA1A P35348 2/20 0.55
CHRM2 P08172 1/20 0.55
DRD1 P21728 1/20 0.55
SLC6A2 P23975 1/20 0.55
OPRM1 P35372 1/20 0.55
DRD3 P35462 1/20 0.55
SLC6A3 Q01959 1/20 0.55
KCNH2 Q12809 1/20 0.55
ALDH1A1 P00352 2/20 0.54
GAA P10253 1/20 0.54
TSHR P16473 1/20 0.54
HRH1 P35367 5/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17698620 0.86 HTR6 (0.58) ADRA2AADRA1ADRD3HRH1HTR6
SCHEMBL17698631 0.82 HTR6 (0.61) CYP1A2CYP2D6HTR1AADRA2ACHRM1
SCHEMBL3317502 0.80 CYP1A2 (0.66) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL18494979 0.77 MAOA (0.76) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL12868566 0.76 CYP1A2 (0.97) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL22055272 0.76 MAOA (0.54) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL13368816 0.76 HRH1 (0.64) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL13368817 0.75 HRH1 (0.61) CYP1A2CYP2D6MAOAMAOBHTR1A
SCHEMBL21420902 0.74 ALDH1A1 (0.52) CYP1A2ALDH1A1TSHRKDM4ELMNA
SCHEMBL2299395 0.74 CYP1A2 (0.69) CYP1A2CYP2D6MAOAMAOBHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2145887-B1 SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND USE THEREOF ALLA CHEM LLC (US) 2016-04-27 EP claimed