Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | CYP17A1 | P05093 | 7/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13689086 | 0.87 | HSD11B1 (0.48) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL1769926 | 0.85 | CYP17A1 (0.52) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL1770371 | 0.81 | ALDH1A1 (0.40) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL1770008 | 0.78 | HSD11B1 (0.67) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL3322539 | 0.77 | ALDH1A1 (0.41) | HSD11B1P2RX7ALDH1A1LMNA | |
| SCHEMBL1769922 | 0.77 | HSD11B1 (0.53) | HSD11B1P2RX7ALDH1A1LMNATSHR | |
| SCHEMBL12649171 | 0.75 | ALDH1A1 (0.35) | HSD11B1CYP17A1CYP19A1MEN1KMT2A | |
| SCHEMBL1769963 | 0.75 | HSD11B1 (0.62) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL1770095 | 0.75 | HSD11B1 (0.62) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 | |
| SCHEMBL3321259 | 0.75 | HSD11B1 (1.00) | HSD11B1CYP17A1CYP19A1P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| EP-2257528-A2 | 1 IBETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106817-A2 | COMPOUND | STERIX LIMITED (GB) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885CYP17A1 23/4885CYP19A1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.