Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | BCL3 | P20749 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121108 | 0.88 | DRD2 (0.55) | KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL14756465 | 0.86 | KMT2A (0.63) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL17706244 | 0.86 | KMT2A (0.65) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL17678080 | 0.86 | LMNA (0.79) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL77220 | 0.86 | KMT2A (0.65) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL17706285 | 0.86 | KMT2A (0.68) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL15250789 | 0.85 | KMT2A (0.62) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL15250780 | 0.85 | KMT2A (0.62) | KMT2AALDH1A1BCL3LMNATSHR | |
| SCHEMBL12124402 | 0.82 | NPSR1 (0.61) | KMT2ABCL3 | |
| SCHEMBL12121155 | 0.81 | RAB9A (0.48) | KMT2AALDH1A1BCL3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751108-B1 | BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION | NOVARTIS AG (CH) | 2016-04-27 | — | — | EP | disclosed |