Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.43 |
| ▸ | HTR3A | P46098 | 10/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415417 | 0.88 | CHRNA7 (0.39) | CHRNA7HTR3ARORCMEN1KMT2A | |
| SCHEMBL1975320 | 0.81 | SLC6A2 (0.44) | CHRNA7HTR3A | |
| SCHEMBL414018 | 0.81 | SLC6A2 (0.44) | CHRNA7HTR3A | |
| SCHEMBL15423390 | 0.80 | CHRNA7 (0.38) | CHRNA7HTR3ARORCMEN1KMT2A | |
| SCHEMBL1971670 | 0.79 | CHRNA7 (0.36) | CHRNA7HTR3ARORCHTT | |
| SCHEMBL15423391 | 0.68 | GPR119 (0.37) | CHRNA7HTR3ARORC | |
| SCHEMBL415193 | 0.67 | CYP2D6 (0.46) | CHRNA7L3MBTL1POLB | |
| SCHEMBL415153 | 0.65 | CYP2D6 (0.62) | CHRNA7HTR3AL3MBTL1 | |
| SCHEMBL12350297 | 0.64 | CHRNA7 (0.42) | CHRNA7HTR3AL3MBTL1 | |
| SCHEMBL2889881 | 0.63 | BCL2L1 (0.53) | CHRNA7HTR3AL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684871-B1 | Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives | HOFFMANN LA ROCHE (CH) | 2016-05-04 | — | — | EP | disclosed |