Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11395507 | 0.84 | NPC1 (0.51) | KMT2AACHE | |
| SCHEMBL11251566 | 0.84 | KMT2A (0.68) | KMT2AITGB3ITGA2BACHEBCHE | |
| SCHEMBL11400510 | 0.81 | TDP1 (0.52) | KMT2AHTR4ACHEHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL9254882 | 0.80 | KMT2A (0.46) | KMT2AHTR4ITGB3ITGA2BACHE | |
| Trifluoroacetic Acid SCHEMBL7734277 | 0.79 | KMT2A (0.48) | KMT2AITGB3ITGA2BACHEBCHE | |
| Trifluoroacetic Acid SCHEMBL7723271 | 0.78 | KMT2A (0.60) | KMT2AITGB3ITGA2BACHEBCHE | |
| SCHEMBL27895732 | 0.78 | LMNA (0.50) | ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL9247289 | 0.77 | HDAC1 (0.48) | KMT2AACHEBCHEHDAC1 | |
| SCHEMBL13987188 | 0.77 | HTR4 (0.61) | HTR4ITGB3ITGA2BACHE | |
| SCHEMBL8132896 | 0.77 | ACHE (0.48) | HTR4ITGB3ITGA2BACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004058-B1 | ACETYLCHOLINESTERASE INHIBITOR COMPOUNDS AND 5HT4 SEROTONERGIC RECEPTOR AGONISTS, WITH PROMNESIA EFFECT, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | UNIV DE CAEN (FR) | 2020-06-10 | — | — | EP | disclosed |
| CN-105705488-B | Compounds of acetylcholinesterase inhibitors and 5-hydroxytryptamine receptor 4 agonists, process for their preparation and pharmaceutical compositions thereof | 卡昂大学 | 2020-03-24 | — | — | CN | disclosed |
| US-9663465-B2 | Acetylcholinesterase inhibitors and promnesiant serotonin 5-HT4 receptor agonists, their methods of preparation and the pharmaceutical compositions containing the same | UNIVERSITE DE CAEN (FR) | 2017-05-30 | — | — | US | disclosed |
| US-20160122300-A1 | ACETYLCHOLINESTERASE INHIBITOR COMPOUNDS AND 5HT4 SEROTONERGIC RECEPTOR AGONISTS, WITH PROMNSIA EFFECT, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UNIVERSITE DE CAEN (FR) | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122300-A1 | ACETYLCHOLINESTERASE INHIBITOR COMPOUNDS AND 5HT4 SEROTONERGIC RECEPTOR AGONISTS, WITH PROMNSIA EFFECT, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | HTR4, CHRNA4, CHRNB4 | KMT2A 2099/4885HTR4 1/4885ITGB3 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.