Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.61 |
| ▸ | NPC1 | O15118 | 12/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.61 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.61 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918623 | 0.77 | PTPN7 (0.77) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL16062688 | 0.75 | NPC1 (1.00) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL3583274 | 0.75 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1MAPTTP53 | |
| SCHEMBL3582734 | 0.73 | GAA (0.75) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL23156521 | 0.73 | NPC1 (0.65) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL29865443 | 0.73 | CASP3 (0.73) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL23152701 | 0.73 | CASP3 (0.73) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL14315172 | 0.72 | MAPT (1.00) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL6228748 | 0.72 | F10 (0.73) | RAB9ASMN1; SMN2NPC1MAPTKMT2A | |
| SCHEMBL12487310 | 0.71 | SMN1; SMN2 (0.71) | RAB9ASMN1; SMN2NPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | SLC29A1, SLC29A2, SLC28A1 | RAB9A 1709/4885SMN1; SMN2 4145/4885NPC1 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.