Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.53 |
| ▸ | ITGAM | P11215 | 4/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16687571 | 0.91 | ENPP2 (0.82) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL12177177 | 0.88 | ENPP2 (0.64) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL16639750 | 0.87 | ENPP2 (0.63) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL12177183 | 0.84 | ENPP2 (0.60) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL684272 | 0.82 | ENPP2 (0.83) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL4892919 | 0.82 | STAT3 (0.75) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL4892925 | 0.82 | STAT3 (0.75) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL684546 | 0.82 | ENPP2 (1.00) | ENPP2TDP1MAPTKDM4EAPEX1 | |
| SCHEMBL16639749 | 0.81 | KMT2A (0.72) | ENPP2TDP1MAPTITGB2ITGAM | |
| SCHEMBL12177765 | 0.81 | ENPP2 (0.78) | ENPP2TDP1MAPTKDM4EAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328105-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | disclosed |