Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | POLB | P06746 | 6/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | CASP3 | P42574 | 1/20 | 0.72 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.72 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.72 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | EIF4E | P06730 | 1/20 | 0.71 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | PTPN22 | Q9Y2R2 | 6/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29883225 | 0.92 | KMT2A (0.83) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL46215 | 0.91 | ENPP2 (0.75) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL14426584 | 0.87 | MEN1 (0.74) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL29651506 | 0.87 | MEN1 (0.74) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL28185420 | 0.87 | MEN1 (0.74) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL16687571 | 0.86 | ENPP2 (0.82) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL29468145 | 0.85 | KMT2A (0.75) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL6392210 | 0.84 | MEN1 (0.87) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL6392207 | 0.84 | MEN1 (0.87) | KMT2AMEN1POLBL3MBTL1NPC1 | |
| SCHEMBL16639750 | 0.84 | ENPP2 (0.63) | KMT2AMEN1POLBL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3243821-B1 | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | GB006 INC (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20170121410-A1 | COMPOSITIONS AND METHODS TO TREAT SOLID TUMORS | WAYNE STATE UNIVERSITY (US) | 2017-05-04 | — | — | US | disclosed |
| US-9328105-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9023876-B2 | Compounds and methods for regulating integrins | ADHAERE PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ATEGRIN, INC. | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121410-A1 | COMPOSITIONS AND METHODS TO TREAT SOLID TUMORS | ITGB8, MMP8, FUT8 | KMT2A 2866/4885MEN1 3438/4885POLB 738/4885 |
| US-20150105435-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRINS | ITGA2, ITGB2, ITGA2B | KMT2A 2195/4885MEN1 2635/4885POLB 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.