SCHEMBL1772108

SCHEMBL1772108

Cc1ccc2sc(SSc3nc4cc(C)ccc4s3)nc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK1 Q15118 3/20 0.55
FBP1 P09467 3/20 0.55
TDP1 Q9NUW8 2/20 0.55
ALDH1A1 P00352 1/20 0.55
ADRA2A P08913 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
DRD2 P14416 1/20 0.55
HPGD P15428 1/20 0.55
ALOX15 P16050 1/20 0.55
ADRA2B P18089 1/20 0.55
ADRA2C P18825 1/20 0.55
DRD1 P21728 1/20 0.55
MC5R P33032 1/20 0.55
OPRM1 P35372 1/20 0.55
DRD3 P35462 1/20 0.55
OPRK1 P41145 1/20 0.55
CCR2 P41597 1/20 0.55
HTR6 P50406 1/20 0.55
SLC6A3 Q01959 1/20 0.55
HSD17B10 Q99714 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23258113 0.92 FBP1 (0.71) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL17153808 0.86 ALOX5 (0.49) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL1771471 0.85 PDK1 (0.62) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL30590786 0.85 PDK1 (0.62) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL31293713 0.81 SMN1; SMN2 (0.44) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL14311766 0.80 CYP1A2 (0.50) ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT
SCHEMBL9393852 0.79 CYP1A2 (0.51) ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT
SCHEMBL92781 0.78 SMN1; SMN2 (0.61) TDP1ALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL11823166 0.77 FBP1 (0.65) PDK1FBP1TDP1ALDH1A1ADRA2A
SCHEMBL10761882 0.77 DYRK1A (0.50) SMN1; SMN2MAPTNPSR1TP53DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559587-B1 Agricultural or industrial tire with reinforced rubber composition GOODYEAR TIRE & RUBBER (US) 2008-08-20 EP claimed
US-20070187030-A1 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY 2007-08-16 US claimed
EP-1559587-A2 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-03 EP claimed
EP-0824080-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2005-06-08 EP claimed
US-20040182486-A1 Agricultural or industrial tire with reinforced rubber composition BERNARD CARLO (LU) 2004-09-23 US claimed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP claimed
US-6330897-B1 PNEUMATIC TIRES WITH SULFUR CONTAINING VULCANIZATION ACCELERATORS WITH THIAZOLE GROUPS BRIDGESTONE CORPORATION (JP) 2001-12-18 US claimed
EP-0818501-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2001-05-16 EP claimed
EP-0818500-B1 Rubber composition for tire tread and pneumatic tire using the rubber composition BRIDGESTONE CORP (JP) 2001-03-21 EP claimed
US-6197890-B1 TIRE HAVING EXCELLENT CONTROLLABILITY AND RIDE QUALITY THROUGHOUT TIRE LIFE BRIDGESTONE CORPORATION (JP) 2001-03-06 US claimed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US claimed
US-6095217-A PERFORMANCE BY; CONTROLLABILITY ON WET ROADS (WET-ROAD PROPERTY) AND CHIPPING RESISTANCE OF TREADS BRIDGESTONE CORPORATION (JP) 2000-08-01 US claimed
US-6075098-A CLOSED CELL FOAMED RUBBER LAYER OF GIVEN EXPANSION RATIO CONTACTS WITH ROAD AND SOLID RUBBER PHASE IN FOAM CONTAINS BIS((4 OR 5)-METHYLBENZOTHIAZOLYL-2)DISULFIDE VULCANIZATION ACCELERATOR; NO DROP IN ICE OR SNOW PERFORMANCE WITH AGING BRIDGESTONE CORPORATION (JP) 2000-06-13 US claimed
EP-0818499-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2000-05-03 EP claimed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP claimed
EP-0824080-A2 Pneumatic tire Bridgestone Corporation (JP) 1998-02-18 EP claimed
EP-0818501-A1 Pneumatic tire Bridgestone Corporation (JP) 1998-01-14 EP claimed
EP-0818499-A1 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1998-01-14 EP claimed
EP-0818500-A1 Rubber composition for tire tread and pneumatic tire using the rubber composition BRIDGESTONE CORPORATION (JP) 1998-01-14 EP claimed
US-9593231-B2 Tire BRIDGESTONE CORPORATION (JP) 2017-03-14 US disclosed
EP-2325242-B1 Rubber composition for cap tread and studless tire SUMITOMO RUBBER IND (JP) 2013-07-10 EP disclosed
US-20120259038-A1 RUBBER COMPOSITION FOR CAP TREAD AND WINTER TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-10-11 US disclosed
EP-1535961-B1 TIRE BRIDGESTONE CORP (JP) 2011-07-13 EP disclosed
EP-2336234-A1 Tire Bridgestone Corporation (JP) 2011-06-22 EP disclosed
EP-2325242-A1 Rubber composition for cap tread and studless tire Sumitomo Rubber Industries, Ltd. (JP) 2011-05-25 EP disclosed
US-20110112214-A1 RUBBER COMPOSITION FOR CAP TREAD AND STUDLESS TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-05-12 US disclosed
EP-1559587-B1 Agricultural or industrial tire with reinforced rubber composition GOODYEAR TIRE & RUBBER (US) 2008-08-20 EP disclosed
US-20070187030-A1 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY 2007-08-16 US disclosed
US-20050250883-A1 Tire BRIDGESTONE CORPORATION 2005-11-10 US disclosed
EP-1559587-A2 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-03 EP disclosed
EP-0824080-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2005-06-08 EP disclosed
EP-1535961-A1 TIRE Bridgestone Corporation (JP) 2005-06-01 EP disclosed
US-20040182486-A1 Agricultural or industrial tire with reinforced rubber composition BERNARD CARLO (LU) 2004-09-23 US disclosed
EP-0869016-B1 Pneumatic radial tires BRIDGESTONE CORP (JP) 2004-03-03 EP disclosed
EP-0945482-B1 Rubber composition for tire tread and pneumatic tire using same BRIDGESTONE CORP (JP) 2004-01-28 EP disclosed
EP-0890605-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2003-04-23 EP disclosed
EP-1277795-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-22 EP disclosed
US-6336486-B1 Pneumatic radical tire having cap base tread BRIDGESTONE CORPORATION (JP) 2002-01-08 US disclosed
US-6330897-B1 PNEUMATIC TIRES WITH SULFUR CONTAINING VULCANIZATION ACCELERATORS WITH THIAZOLE GROUPS BRIDGESTONE CORPORATION (JP) 2001-12-18 US disclosed
US-6242522-B1 A DIENE BASED SYNTHETIC RUBBER OR NATURAL RUBBER BLEND CONTAINING BUTADIENE-STYRENE RUBBER, ALUMINUM HYDROXIDE POWDER, SILICA POWDER, CARBON BLACK; LOW FUEL CONSUMPTION AND WEAR RESISTANCE; IMPROVED GRIPPING IN WET AND COLD SITUATIONS BRIDGESTONE CORPORATION (JP) 2001-06-05 US disclosed
EP-0818501-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2001-05-16 EP disclosed
EP-0818500-B1 Rubber composition for tire tread and pneumatic tire using the rubber composition BRIDGESTONE CORP (JP) 2001-03-21 EP disclosed
US-6197890-B1 TIRE HAVING EXCELLENT CONTROLLABILITY AND RIDE QUALITY THROUGHOUT TIRE LIFE BRIDGESTONE CORPORATION (JP) 2001-03-06 US disclosed
US-6197890-B1 TIRE HAVING EXCELLENT CONTROLLABILITY AND RIDE QUALITY THROUGHOUT TIRE LIFE BRIDGESTONE CORPORATION (JP) 2001-03-06 US disclosed
US-6186204-B1 EXCELLENT STABILITY AND CONTROLLABILITY ON WET ROADS OR A COMBINATION OF STABILITY AND CONTROLLABILITY ON WET ROADS AND EXCELLENT COMFORT OF RIDE EVEN WHEN A VEHICLE IS VIBRATING THROUGHOUT THE LIFE OF THE PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2001-02-13 US disclosed
US-6095217-A PERFORMANCE BY; CONTROLLABILITY ON WET ROADS (WET-ROAD PROPERTY) AND CHIPPING RESISTANCE OF TREADS BRIDGESTONE CORPORATION (JP) 2000-08-01 US disclosed
US-6095217-A PERFORMANCE BY; CONTROLLABILITY ON WET ROADS (WET-ROAD PROPERTY) AND CHIPPING RESISTANCE OF TREADS BRIDGESTONE CORPORATION (JP) 2000-08-01 US disclosed
US-6075098-A CLOSED CELL FOAMED RUBBER LAYER OF GIVEN EXPANSION RATIO CONTACTS WITH ROAD AND SOLID RUBBER PHASE IN FOAM CONTAINS BIS((4 OR 5)-METHYLBENZOTHIAZOLYL-2)DISULFIDE VULCANIZATION ACCELERATOR; NO DROP IN ICE OR SNOW PERFORMANCE WITH AGING BRIDGESTONE CORPORATION (JP) 2000-06-13 US disclosed
EP-0818499-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2000-05-03 EP disclosed
EP-0948029-A2 High pressure discharge lamp NGK INSULATORS, LTD. (JP) 1999-10-06 EP disclosed
EP-0890605-A2 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1999-01-13 EP disclosed
EP-0869016-A2 Pneumatic radial tires Bridgestone Corporation (JP) 1998-10-07 EP disclosed
EP-0824080-A2 Pneumatic tire Bridgestone Corporation (JP) 1998-02-18 EP disclosed
EP-0818501-A1 Pneumatic tire Bridgestone Corporation (JP) 1998-01-14 EP disclosed
EP-0818501-A1 Pneumatic tire Bridgestone Corporation (JP) 1998-01-14 EP disclosed
EP-0818500-A1 Rubber composition for tire tread and pneumatic tire using the rubber composition BRIDGESTONE CORPORATION (JP) 1998-01-14 EP disclosed
EP-0818499-A1 Pneumatic tire BRIDGESTONE CORPORATION (JP) 1998-01-14 EP disclosed
EP-0818500-A1 Rubber composition for tire tread and pneumatic tire using the rubber composition BRIDGESTONE CORPORATION (JP) 1998-01-14 EP disclosed
US-4343660-A PETROLEUM SULFONATE AND COMPLEXING AGENT, FOR COPPER CABLES PETROLITE CORPORATION (US) 1982-08-10 US disclosed
US-4138346-A ETHOXYLATED PHOSPHATE ESTER WITH A MERCAPTOTHIAZOLE, A DITHIOBIS-THIAZOLE, A SULFIDE, A DISULFIDE OR A SULFONE BASF WYANDOTTE CORPORATION (US) 1979-02-06 US disclosed
US-4138346-A ETHOXYLATED PHOSPHATE ESTER WITH A MERCAPTOTHIAZOLE, A DITHIOBIS-THIAZOLE, A SULFIDE, A DISULFIDE OR A SULFONE BASF WYANDOTTE CORPORATION (US) 1979-02-06 US disclosed