Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772758 | 0.76 | CYP3A4 (0.44) | CYP3A4CYP2C19MEN1ALOX15KMT2A | |
| SCHEMBL1771745 | 0.69 | SLC6A4 (0.45) | SLC6A4SLC6A3 | |
| SCHEMBL1772772 | 0.67 | TACR3 (0.33) | CYP3A4CYP2C19ALOX15CYP2C9CCR2 | |
| SCHEMBL1781064 | 0.65 | SLC6A3 (0.46) | CCR2SLC6A4SLC6A3 | |
| SCHEMBL19839249 | 0.64 | ABCB1 (0.43) | CYP3A4CYP2C19MEN1CYP2D6ALOX15 | |
| SCHEMBL1772419 | 0.64 | MAPT (0.38) | CYP3A4CYP2C19MEN1CYP2D6KMT2A | |
| SCHEMBL23933305 | 0.62 | SLC6A3 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL30138625 | 0.62 | SLC6A3 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL23961568 | 0.62 | SLC6A3 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL3984092 | 0.60 | ADAM17 (0.53) | CCR2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326634-B1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2014-11-05 | — | — | EP | disclosed |
| US-20140235672-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2014-08-21 | — | — | US | disclosed |
| US-8759390-B2 | Chromene modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-06-24 | — | — | US | disclosed |
| EP-2326634-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2011-06-01 | — | — | EP | disclosed |
| US-20110112146-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2011-05-12 | — | — | US | disclosed |
| WO-2010009069-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235672-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | CCR1, CCR3, CCR2 | CYP3A4 759/4885CYP2C19 612/4885MEN1 3570/4885 |
| US-20110112146-A1 | CHROMENE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | CCR1, CCR3, CCR2 | CYP3A4 913/4885CYP2C19 677/4885MEN1 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.