Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.38 |
| ▸ | METAP1 | P53582 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 3/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15943367 | 0.85 | AHR (0.48) | KMOKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6512405 | 0.81 | ESR2 (0.46) | METAP2METAP1CHEK2KDM4AKDM4B | |
| SCHEMBL4524262 | 0.81 | KMO (0.47) | METAP2METAP1SCN9ACHEK2KMO | |
| SCHEMBL14754382 | 0.77 | KMO (0.47) | METAP2METAP1SCN9ACHEK2KDM4A | |
| SCHEMBL15384396 | 0.77 | KMO (0.50) | SCN9AKMOMAPTL3MBTL1MEN1 | |
| SCHEMBL26260183 | 0.75 | CYP1A2 (0.43) | METAP2METAP1SCN9ACHEK2KDM4A | |
| SCHEMBL679357 | 0.75 | METAP2 (0.46) | METAP2METAP1KDM4EMAPTNPC1 | |
| SCHEMBL6516629 | 0.74 | P2RX7 (0.41) | CHEK2KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL28200395 | 0.74 | CHEK2 (0.38) | METAP2METAP1SCN9ACHEK2KDM4A | |
| SCHEMBL4521043 | 0.74 | IDO1 (0.50) | METAP2METAP1SCN9ACHEK2KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| WO-2009121535-A2 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA`DEGLI STUDI DI MILANO - BICOCCA (IT) | 2009-10-08 | — | — | WO | disclosed |
| EP-2107054-A1 | Antiproliferative compounds and therapeutic uses thereof | Università Degli Studi Di Milano - Bicocca (IT) | 2009-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | ABL1, MKI67, BCR | METAP2 2913/4885METAP1 2248/4885SCN9A 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.