Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | TPH1 | P17752 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL15971910 | 0.93 | DPP4 (0.34) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| Proline SCHEMBL17728310 | 0.92 | PTPN1 (0.43) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| SCHEMBL4542258 | 0.89 | PTPN1 (0.45) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| Threonine SCHEMBL9058511 | 0.88 | SLC7A5 (0.36) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| Tyrosine SCHEMBL12497090 | 0.87 | SLC7A5 (0.51) | SLC7A5DPP4CTSCPTGS1ALPI | |
| Tyrosine SCHEMBL12497096 | 0.87 | SLC7A5 (0.51) | SLC7A5DPP4CTSCPTGS1ALPI | |
| Tyrosine SCHEMBL17728294 | 0.87 | SLC7A5 (0.51) | SLC7A5DPP4CTSCPTGS1ALPI | |
| Dl-Phenylalanine SCHEMBL27660741 | 0.87 | SLC7A5 (0.49) | SLC7A5HTR2CHTR2BDPP4FAP | |
| Threonine SCHEMBL17728307 | 0.87 | DPP4 (0.33) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| Threonine SCHEMBL15972069 | 0.84 | ITGB3 (0.35) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958971-B1 | MULTI COMPONENT ADHESIVE FOR THE PREPARATION OF ADHESIVE HYDROGELS | FRAUNHOFER GES FORSCHUNG (DE) | 2018-07-11 | — | — | EP | claimed |
| US-20160130484-A1 | MULTI-COMPONENT ADHESIVE FOR PRODUCING AN ADHESIVE HYDROGEL | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2016-05-12 | — | — | US | claimed |
| US-20160130484-A1 | MULTI-COMPONENT ADHESIVE FOR PRODUCING AN ADHESIVE HYDROGEL | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2016-05-12 | — | — | US | disclosed |