Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649148 | 0.79 | HDAC3 (0.58) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL16492277 | 0.79 | HDAC3 (0.58) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL15809775 | 0.76 | KMT2A (0.73) | KMT2A | |
| SCHEMBL5863481 | 0.75 | KMT2A (0.51) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL11571372 | 0.74 | TAAR1 (0.48) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL9398200 | 0.73 | HDAC3 (0.59) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL6649484 | 0.72 | LMNA (0.69) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL4597996 | 0.71 | HDAC3 (0.56) | DRD2DRD4DRD3HDAC3HDAC4 | |
| SCHEMBL18025027 | 0.71 | KMT2A (0.39) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL7338781 | 0.71 | KMT2A (0.70) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934251-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2021-03-02 | — | — | US | claimed |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2020-06-18 | — | — | US | claimed |
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | claimed |
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-04-19 | — | — | US | claimed |
| EP-3215490-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | Hetero Research Foundation (IN) | 2017-09-13 | — | — | EP | claimed |
| WO-2016071849-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2016-05-12 | — | — | WO | claimed |
| US-10934251-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2021-03-02 | — | — | US | disclosed |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | HETERO RESEARCH FOUNDATION (IN) | 2020-06-18 | — | — | US | disclosed |
| US-20180291773-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-10-11 | — | — | US | disclosed |
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-04-19 | — | — | US | disclosed |
| EP-3215490-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | Hetero Research Foundation (IN) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016071849-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | LIPA, LPAR4, CETP | DRD2 2739/4885DRD4 2295/4885DRD3 2391/4885 |
| US-10023526-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | DRD2 2739/4885DRD4 2295/4885DRD3 2391/4885 |
| US-20200190018-A1 | Process For The Preparation of Lomitapide | LIPA, LPAR4, CETP | DRD2 2739/4885DRD4 2295/4885DRD3 2391/4885 |
| US-10934251-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | DRD2 2739/4885DRD4 2295/4885DRD3 2391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.