Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21925532 | 0.83 | HDAC3 (0.54) | LMNAHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL4669452 | 0.82 | LMNA (1.00) | LMNAHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL9953442 | 0.81 | KCNA5 (0.53) | LMNAUSP2ALDH1A1HPGDMC4R | |
| SCHEMBL9398200 | 0.81 | HDAC3 (0.59) | LMNAHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL11800163 | 0.80 | KCNA5 (0.55) | LMNAALDH1A1MC4RKCNA5DRD2 | |
| SCHEMBL9959313 | 0.77 | KCNA5 (0.48) | LMNAUSP2ALDH1A1HPGDMC4R | |
| SCHEMBL16492277 | 0.76 | HDAC3 (0.58) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL6649148 | 0.76 | HDAC3 (0.58) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL11166921 | 0.75 | LMNA (0.56) | LMNAUSP2ALDH1A1HPGDMC4R | |
| SCHEMBL4597996 | 0.75 | HDAC3 (0.56) | LMNAHDAC3HDAC4HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904262-B1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6472414-B1 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-29 | — | — | US | disclosed |
| EP-0904262-A4 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0904262-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5760246-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 1998-06-02 | — | — | US | disclosed |
| WO-1997026240-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |