SCHEMBL17735857

SCHEMBL17735857

O=C1c2ccc(Cc3ccc4c(c3)C(=O)N(CCO)C4=O)cc2C(=O)N1CCO

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.69
ALDH1A1 P00352 5/20 0.51
MEN1 O00255 4/20 0.51
KMT2A Q03164 4/20 0.51
HTT P42858 2/20 0.51
TSHR P16473 1/20 0.51
HSD17B10 Q99714 2/20 0.50
MAPK1 P28482 1/20 0.50
HEXA P06865 1/20 0.49
HEXB P07686 1/20 0.49
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
RGS12 O14924 1/20 0.47
LMNA P02545 1/20 0.47
PABPC1 P11940 1/20 0.47
RECQL P46063 1/20 0.47
GAA P10253 1/20 0.42
CASP1 P29466 1/20 0.42
ENPP2 Q13822 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17735854 0.85 KDM4E (0.49) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL15056310 0.81 KDM4E (1.00) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL10909810 0.80 KDM4E (0.71) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL13020839 0.80 KDM4E (0.56) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL3582064 0.79 KDM4E (0.69) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL5878681 0.79 KDM4E (0.69) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL10053599 0.79 KDM4E (0.69) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL10000449 0.78 ALDH1A1 (0.47) KDM4EALDH1A1MEN1KMT2ATSHR
SCHEMBL19930109 0.78 POLB (0.54) KDM4EALDH1A1MEN1KMT2AHTT
SCHEMBL12979028 0.78 KDM4E (0.54) KDM4EALDH1A1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180066111-A1 COPOLYESTERIMIDES DERIVED FROM N,N'-BIS-(HYDROXYALKYL)-BENZOPHENONE-3,3',4,4'-TETRACARBOXYLIC DIIMIDE AND FILMS MADE THEREFROM DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP (US) 2018-03-08 US disclosed
US-9840590-B2 Copolyesterimides derived from N,N′-bis-(hydroxyalkyl)-benzophenone-3,3′,4,4′-tetracarboxylic diimide and films made therefrom DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP (US) 2017-12-12 US disclosed
US-9422399-B2 Copolyesterimides derived from N,N′-bis-(hydroxyalkyl)-3,3′,4,4′-diphenylsulfonetetracarboxylic diimide and films made therefrom DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP (US) 2016-08-23 US disclosed
US-20160137790-A1 COPOLYESTERIMIDES DERIVED FROM N,N'-BIS-(HYDROXYALKYL)-BENZOPHENONE-3,3',4,4'-TETRACARBOXYLIC DIIMIDE AND FILMS MADE THEREFROM DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP (US) 2016-05-19 US disclosed
US-20160130399-A1 COPOLYESTERIMIDES DERIVED FROM N,N'-BIS-(HYDROXYALKYL)-3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIIMIDE AND FILMS MADE THEREFROM DUPONT TEIJIN FILMS U.S. LIMITED PARTNERSHIP (US) 2016-05-12 US disclosed