Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | CASP1 | P29466 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | CASP7 | P55210 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HEXA | P06865 | 1/20 | 0.49 |
| ▸ | HEXB | P07686 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005568 | 0.82 | CASP1 (0.60) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL15056310 | 0.81 | KDM4E (1.00) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL10909810 | 0.80 | KDM4E (0.71) | KDM4EHSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL2651666 | 0.79 | HSD17B10 (0.66) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL25358575 | 0.79 | HSD17B10 (1.00) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL17735857 | 0.79 | KDM4E (0.69) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL5878681 | 0.79 | KDM4E (0.69) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL10053599 | 0.79 | KDM4E (0.69) | KDM4EHSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL17077235 | 0.78 | HSD17B10 (0.64) | KDM4EHSD17B10CASP1MEN1KMT2A | |
| SCHEMBL211513 | 0.78 | CYP2D6 (0.60) | HSD17B10CASP1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| EP-1954132-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| EP-0716666-B1 | TONERS FOR POLYESTERS | EASTMAN CHEM CO (US) | 1998-05-13 | — | — | EP | disclosed |
| EP-0716666-A1 | TONERS FOR POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1996-06-19 | — | — | EP | disclosed |
| WO-1995006677-A1 | TONERS FOR POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1995-03-09 | — | — | WO | disclosed |
| US-5384377-A | Anthraquinone and anthrapyridone compounds provide neutral to blue hue to yellow-appearing polyesters | EASTMAN CHEMICAL COMPANY (US) | 1995-01-24 | — | — | US | disclosed |
| US-5372864-A | Whiteners | EASTMAN CHEMICAL COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| US-4324719-A | YELLOW TO BLUE SHADES ON NYLON CARPET | EASTMAN KODAK COMPANY (US) | 1982-04-13 | — | — | US | disclosed |
| US-4039522-A | Phthalimidyl-azo-m-acylamido-n-substituted aniline compounds and polyester fibers dyed therewith | EASTMAN KODAK COMPANY (US) | 1977-08-02 | — | — | US | disclosed |
| US-4012372-A | MONOAZO DISPERSE DYES | EASTMAN KODAK COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-3980634-A | Phthalimidyl-azo aniline type compounds and polyester fibers dyed therewith | EASTMAN KODAK COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | KDM4E 4075/4885HSD17B10 3107/4885CASP1 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.