Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.53 |
| ▸ | METAP1 | P53582 | 3/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.43 |
| ▸ | GLRB | P48167 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28787393 | 0.94 | METAP2 (0.48) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL249779 | 0.87 | METAP2 (0.64) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL12578335 | 0.82 | METAP2 (0.51) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL1773802 | 0.81 | ENPP1 (0.54) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL7023211 | 0.81 | DRD2 (0.42) | KDM4EMAPTALDH1A1 | |
| SCHEMBL16926997 | 0.79 | DRD2 (0.41) | LMNAKDM4EMAPTRAB9APOLB | |
| SCHEMBL27854709 | 0.78 | CCR1 (0.47) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL1773202 | 0.76 | SLC22A12 (0.44) | LMNAKDM4E | |
| SCHEMBL28787391 | 0.76 | ENPP1 (0.55) | METAP2METAP1SLC40A1PDE4APDE4C | |
| SCHEMBL16582721 | 0.76 | ERN1 (0.51) | METAP2METAP1SLC40A1PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112103-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112103-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND | EPOR, CBR1, CBR3 | METAP2 1193/4885METAP1 1416/4885SLC40A1 1853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.