Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17739322 | 0.82 | ALDH1A1 (0.50) | ALDH1A1RECQLKDM4ELMNALRRK2 | |
| SCHEMBL17738485 | 0.81 | TRPV1 (0.45) | TRPV1 | |
| SCHEMBL17738539 | 0.80 | ALDH1A1 (0.52) | ALDH1A1LMNAJAK2JAK1TRPV1 | |
| SCHEMBL21894786 | 0.79 | TRPV1 (0.40) | TRPV1LRRK2IDO1NOS1 | |
| SCHEMBL17738867 | 0.76 | ALDH1A1 (0.48) | ALDH1A1JAK2JAK1TRPV1LRRK2 | |
| SCHEMBL30146781 | 0.75 | ROCK2 (0.43) | ALDH1A1LMNATRPV1LRRK2IDO1 | |
| SCHEMBL18324788 | 0.75 | KDM4E (0.46) | ALDH1A1RECQLKDM4ELMNALRRK2 | |
| SCHEMBL17739258 | 0.74 | IDO1 (0.69) | JAK2JAK1TRPV1IDO1TDO2 | |
| SCHEMBL17738491 | 0.74 | TRPV1 (0.46) | ALDH1A1LMNAJAK2JAK1TRPV1 | |
| SCHEMBL17738480 | 0.73 | TRPV1 (0.44) | JAK2JAK1TRPV1LRRK2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11130738-B2 | Pharmaceutical compound | IOMET PHARMA LTD. (GB) | 2021-09-28 | — | — | US | disclosed |
| US-20200172492-A1 | PHARMACEUTICAL COMPOUND | IOMET PHARMA LTD. (GB) | 2020-06-04 | — | — | US | disclosed |
| US-10590086-B2 | Pharmaceutical compound | IOMET PHARMA LTD. (GB) | 2020-03-17 | — | — | US | disclosed |
| WO-2016071293-A2 | PHARMACEUTICAL COMPOUND | IOMET PHARMA LTD (GB) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130738-B2 | Pharmaceutical compound | IDO1, TDO2, IDO2 | ALDH1A1 1976/4885RECQL 1857/4885KDM4E 428/4885 |
| US-20200172492-A1 | PHARMACEUTICAL COMPOUND | IDO1, TDO2, IDO2 | ALDH1A1 1976/4885RECQL 1857/4885KDM4E 428/4885 |
| US-10590086-B2 | Pharmaceutical compound | IDO1, TDO2, IDO2 | ALDH1A1 1976/4885RECQL 1857/4885KDM4E 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.