Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177394 | 0.89 | S1PR1 (0.61) | S1PR1TAS2R14S1PR5NPSR1MAPT | |
| SCHEMBL177393 | 0.82 | S1PR1 (0.53) | S1PR1TAS2R14NPSR1MAPTKMT2A | |
| SCHEMBL177154 | 0.81 | S1PR5 (0.49) | S1PR1TAS2R14S1PR5 | |
| SCHEMBL177470 | 0.76 | HSD17B1 (0.42) | S1PR1LMNAMAPTKMT2AHTT | |
| SCHEMBL177204 | 0.76 | S1PR1 (1.00) | S1PR1S1PR5HTT | |
| SCHEMBL177452 | 0.74 | S1PR1 (0.55) | S1PR1LMNATDP1SMN1; SMN2NPSR1 | |
| SCHEMBL178252 | 0.72 | S1PR1 (0.79) | S1PR1S1PR5 | |
| SCHEMBL15512145 | 0.69 | HSD17B1 (0.41) | TAS2R14LMNAMAPTKMT2AHTT | |
| SCHEMBL3036912 | 0.66 | S1PR5 (0.64) | S1PR1LMNAS1PR5MAPTALDH1A1 | |
| SCHEMBL9996186 | 0.62 | S1PR1 (0.70) | S1PR1S1PR5ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344484-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | Akaal Pharma Pty Ltd (AU) | 2011-07-20 | — | — | EP | claimed |
| WO-2010043000-A1 | S1P RECEPTORS MODULATORS AND THEIR USE THEREOF | AKAAL PHARMA PTY LTD (AU) | 2010-04-22 | — | — | WO | claimed |