Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 12/20 | 0.69 |
| ▸ | MAPT | P10636 | 10/20 | 0.69 |
| ▸ | NPC1 | O15118 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | F10 | P00742 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778815 | 0.84 | MEN1 (0.73) | KMT2AMEN1ATMRAB9AMAPT | |
| Hydrochloric Acid SCHEMBL18045308 | 0.84 | KMT2A (0.95) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL2466729 | 0.82 | MAPT (1.00) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL12117491 | 0.78 | LMNA (0.49) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL4921277 | 0.77 | MAPT (0.75) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL12319804 | 0.77 | TMPRSS4 (0.69) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL14825327 | 0.75 | KMT2A (0.70) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL22778848 | 0.74 | MEN1 (0.69) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL22778818 | 0.73 | ALDH1A1 (0.63) | KMT2AMEN1ATMRAB9AMAPT | |
| SCHEMBL4972639 | 0.73 | CYP1A2 (0.72) | KMT2AMEN1RAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016073633-A1 | SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP) | UNIVERSITY OF KANSAS (US) | 2016-05-12 | — | — | WO | disclosed |