SCHEMBL12117491

SCHEMBL12117491

Cc1ccc(N2CCCCC2)cc1C(=O)Nc1cc(Cl)ccc1C#N

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.49
▸ MAPT P10636 3/20 0.48
▸ SERPINE1 P05121 2/20 0.47
▸ KMT2A Q03164 4/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ ATM Q13315 2/20 0.47
▸ ALDH1A1 P00352 6/20 0.45
▸ GAA P10253 3/20 0.45
▸ L3MBTL1 Q9Y468 3/20 0.45
▸ NPC1 O15118 2/20 0.45
▸ RAB9A P51151 2/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45
▸ KDM4E B2RXH2 3/20 0.44
▸ HPGD P15428 2/20 0.44
▸ CSF1R P07333 4/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12117492 0.85 ALDH1A1 (0.47) LMNAMAPTKMT2AMEN1ATM
SCHEMBL12121803 0.82 KMT2A (0.46) LMNAMAPTSERPINE1KMT2AMEN1
SCHEMBL1314992 0.80 LRRK2 (0.59) KMT2AMEN1ALDH1A1NPC1RAB9A
SCHEMBL17740321 0.78 KMT2A (0.75) LMNAMAPTKMT2AMEN1ATM
SCHEMBL4302460 0.70 SIRT6 (0.47) LMNAMAPTKMT2AMEN1ALDH1A1
SCHEMBL14036785 0.70 LMNA (0.50) LMNAMAPTKMT2AMEN1ALDH1A1
SCHEMBL4296080 0.69 IP6K1 (0.60) LMNAMAPTSERPINE1KMT2AMEN1
SCHEMBL4342270 0.69 ALDH1A1 (0.58) LMNAMAPTKMT2AMEN1ATM
SCHEMBL20972831 0.68 MAPT (0.48) LMNAMAPTKMT2AMEN1ALDH1A1
SCHEMBL14036781 0.68 LMNA (0.51) LMNAMAPTKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 — — US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 LMNA 546/4885MAPT 4045/4885SERPINE1 470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback