Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | FOS | P01100 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773964 | 0.87 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1774892 | 0.87 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1774655 | 0.85 | MAPT (0.62) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1773901 | 0.85 | MAPT (0.62) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1774366 | 0.85 | MAPT (0.62) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1773691 | 0.85 | MAPT (0.44) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL2174009 | 0.85 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1774479 | 0.85 | MAPT (0.61) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL1775769 | 0.83 | ALDH1A1 (0.59) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 | |
| SCHEMBL4702653 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2SYKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943608-B2 | Diazepinoes | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| US-20080318934-A1 | Diazepinoes | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318934-A1 | Diazepinoes | CDK1, MAP3K11, MAP3K1 | ALDH1A1 1652/4885MAPT 904/4885SMN1; SMN2 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.