Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | SYK | P43405 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773964 | 0.92 | MAPT (0.64) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1774109 | 0.87 | ALDH1A1 (0.63) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL2174009 | 0.87 | ALDH1A1 (0.76) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1773998 | 0.86 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1773787 | 0.84 | MAPT (0.60) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1774655 | 0.84 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1774366 | 0.84 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1773901 | 0.84 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL4699968 | 0.84 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2SYKHTT | |
| SCHEMBL1774479 | 0.83 | MAPT (0.61) | MAPTALDH1A1SMN1; SMN2SYKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943608-B2 | Diazepinoes | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| US-20080318934-A1 | Diazepinoes | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318934-A1 | Diazepinoes | CDK1, MAP3K11, MAP3K1 | MAPT 904/4885ALDH1A1 1652/4885SMN1; SMN2 2997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.