Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | SYK | P43405 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | FOS | P01100 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848560 | 0.89 | MAPT (0.78) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774892 | 0.87 | MAPT (0.64) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1773964 | 0.87 | MAPT (0.64) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774929 | 0.86 | SYK (0.62) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774366 | 0.85 | MAPT (0.62) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1773901 | 0.85 | MAPT (0.62) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774655 | 0.85 | MAPT (0.62) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774109 | 0.85 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1774479 | 0.85 | MAPT (0.61) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 | |
| SCHEMBL1313596 | 0.84 | SYK (0.79) | ALDH1A1SMN1; SMN2MAPTSYKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470812-B2 | Substituted benzo-pyrimido-tetrazolo-diazepine compounds | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470812-B2 | Substituted benzo-pyrimido-tetrazolo-diazepine compounds | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8470812-B2 | Substituted benzo-pyrimido-tetrazolo-diazepine compounds | ARQULE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110166127-A1 | Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166127-A1 | Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166127-A1 | Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| WO-2011082269-A2 | SUBSTITUTED BENZO-PYRIMIDO-TETRAZOLO-DIAZEPINE COMPOUNDS | ARQULE, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011082269-A2 | SUBSTITUTED BENZO-PYRIMIDO-TETRAZOLO-DIAZEPINE COMPOUNDS | ARQULE, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| EP-1664053-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1664053-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1664053-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050070554-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-03-31 | — | — | US | disclosed |
| WO-2005021551-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070554-A1 | Substituted heterocyclic compounds and methods of use | NFATC1, ICOS, PAICS | ALDH1A1 774/4885SMN1; SMN2 274/4885MAPT 2631/4885 |
| US-20110166127-A1 | Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds | THPO, DHFR, BRD4 | ALDH1A1 1037/4885SMN1; SMN2 1771/4885MAPT 1923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.