SCHEMBL17742291

SCHEMBL17742291

CNc1c(Br)cc(C)cc1Br

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.45
RAB9A P51151 1/20 0.38
RAPGEF4 Q8WZA2 5/20 0.38
NOS3 P29474 1/20 0.36
NOS2 P35228 1/20 0.36
ALDH2 P05091 1/20 0.33
ALDH3A1 P30838 1/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
XDH P47989 1/20 0.32
TSHR P16473 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31716067 0.84 RAPGEF4 (0.39) ALDH1A1RAB9ARAPGEF4NOS3NOS2
SCHEMBL15868321 0.84 ALDH1A1 (0.39) ALDH1A1RAB9ARAPGEF4NOS3NOS2
SCHEMBL30443265 0.84 ALDH1A1 (0.39) ALDH1A1RAB9ARAPGEF4NOS3NOS2
SCHEMBL12912146 0.77 MYC (0.50) ALDH1A1RAB9AKDM4ESMN1; SMN2
SCHEMBL15868319 0.76 ALDH1A1 (0.49) ALDH1A1KDM4ETSHRMAPTHPGD
SCHEMBL1117704 0.76 GAA (0.45) ALDH1A1RAPGEF4SMN1; SMN2MAPTHPGD
Hydrochloric Acid SCHEMBL15329321 0.72 ALDH1A1 (0.50) ALDH1A1RAB9ARAPGEF4ALDH2ALDH3A1
SCHEMBL22466621 0.71 ALDH1A1 (0.58) ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT
SCHEMBL246412 0.71 RAPGEF4 (0.63) ALDH1A1RAPGEF4
SCHEMBL11334768 0.70 RAPGEF4 (0.48) ALDH1A1RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3466946-B1 THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME DONGBAO PURPLE STAR HANGZHOU BIOPHARMACEUTICAL CO LTD (CN) 2023-08-30 EP disclosed
EP-3466946-A1 THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME CSTONE PHARMACEUTICALS (SHANGHAI) CO., LTD. (CN) 2019-04-10 EP disclosed
WO-2016073750-A1 METATHESIS CATALYSTS AND METHODS THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-05-12 WO disclosed