SCHEMBL246412

SCHEMBL246412

CNc1c(C)cc(C)cc1C

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 16/20 0.63
ALDH1A1 P00352 1/20 0.50
FFAR4 Q5NUL3 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27265861 0.82 RAPGEF4 (0.57) RAPGEF4ALDH1A1FFAR4
SCHEMBL23009590 0.82 RAPGEF4 (0.50) RAPGEF4ALDH1A1
SCHEMBL19629086 0.78 RAPGEF4 (0.46) RAPGEF4ALDH1A1FFAR4
SCHEMBL502929 0.78 RAPGEF4 (1.00) RAPGEF4
SCHEMBL14878894 0.77 ALDH1A1 (0.43) RAPGEF4ALDH1A1
SCHEMBL29021130 0.77 HTR1D (0.41) RAPGEF4ALDH1A1
SCHEMBL24849731 0.77 CYP3A4 (0.55) RAPGEF4ALDH1A1
SCHEMBL5094596 0.75 METAP2 (0.57) RAPGEF4ALDH1A1
SCHEMBL8204442 0.75 ALDH1A1 (0.50) RAPGEF4ALDH1A1FFAR4
SCHEMBL18495129 0.75 RAPGEF4 (0.41) RAPGEF4ALDH1A1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117925054-A Water-based epoxy antirust paint and preparation method thereof 江门市制漆厂有限公司 2024-04-26 CN claimed
US-20200369689-A1 Arylaminosilane Compound, Propylene Polymerization Catalyst And Preparation Thereof PETROCHINA COMPANY LIMITED (CN) 2020-11-26 US claimed
CN-111978346-A Arylamine silane compound, propylene polymerization catalyst, preparation and application thereof 中国石油天然气股份有限公司 2020-11-24 CN claimed
CN-107698697-A A kind of triazole of claw type 1,4 connects cyclodextrin molecular and preparation method and application more 昆明理工大学 2018-02-16 CN claimed
US-20090107555-A1 Dual Function Fuel Atomizing and Ignition Additives AFTON CHEMICAL CORPORATION 2009-04-30 US claimed
EP-1066269-B1 TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS JANSSEN PHARMACEUTICA NV (BE) 2005-05-11 EP claimed
US-20020115668-A1 Trisubstituted 1,3,5-triazine derivatives DAEYAERT FREDERIK FRANS DESIRE (BE) 2002-08-22 US claimed
EP-1066269-A1 TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 2001-01-10 EP claimed
US-6150360-A ADMINISTERING TO A PATIENT SUFFERING FROM HUMAN IMMUNODEFICIENCY VIRUS INFECTION A TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVE JANSSEN PHARMACEUTICA N.V. (BE) 2000-11-21 US claimed
WO-1999050256-A1 TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1999-10-07 WO claimed
CN-117925054-A Water-based epoxy antirust paint and preparation method thereof 江门市制漆厂有限公司 2024-04-26 CN disclosed
US-20240018279-A1 Cyclic Containing Polymer Compositions Obtained Using Transition Metal Bis(Phenolate) Catalyst Complexes and Process for Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2024-01-18 US disclosed
EP-3911647-B1 ISOXAZOLE COMPOUND AS FXR AGONIST AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME GILEAD SCIENCES INC (US) 2023-12-13 EP disclosed
EP-3341358-B1 PREPARATION OF SULFONAMIDE-CONTAINING ANTIMICROBIALS AND SUBSTRATE TREATING COMPOSITIONS OF SULFONAMIDE-CONTAINING ANTIMICROBIALS NANO SAFE COATINGS INCORPORATED A FLORIDA CORP 3 P 14000024914 (US) 2023-03-08 EP disclosed
US-11535638-B2 Arylaminosilane compound, propylene polymerization catalyst and preparation thereof PETROCHINA COMPANY LIMITED (CN) 2022-12-27 US disclosed
WO-1999050256-A1 TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1999-10-07 WO disclosed
CN-1008101-B PROCESS OF PRODUCTION FOR POLYPHENYL ETHER ASAHI CHEMICAL IND (JP) 1990-05-23 CN disclosed
US-4788277-A OXIDATIVE COUPLING, CATALYST CONTAINING COPPER, DIAMINE, HALOGEN ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-11-29 US disclosed
CN-87107289-A The production method of polyphenylene oxide 1988-06-15 CN disclosed
US-4254214-A BLACK, REDUCTION OF COPPER SALT OR COMPLEX TO COPPER FUJI PHOTO FILM CO., LTD. (JP) 1981-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115668-A1 Trisubstituted 1,3,5-triazine derivatives XDH, CCR5, CXCR1 RAPGEF4 4453/4885ALDH1A1 3722/4885FFAR4 997/4885
US-11535638-B2 Arylaminosilane compound, propylene polymerization catalyst and preparation thereof RPS8, PARP8, PRMT8 RAPGEF4 668/4885ALDH1A1 2737/4885FFAR4 1936/4885
US-20200369689-A1 Arylaminosilane Compound, Propylene Polymerization Catalyst And Preparation Thereof RPS8, PARP8, PRMT8 RAPGEF4 668/4885ALDH1A1 2737/4885FFAR4 1936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.