Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 5/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.30 |
| ▸ | HPGD | P15428 | 3/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 2/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.30 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.30 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7627601 | 0.97 | MAOB (0.33) | MEN1KMT2AALDH1A1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL820215 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL31024198 | 0.77 | MAPT (0.33) | MEN1KMT2AALDH1A1L3MBTL1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6465281 | 0.77 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| Hydrochloric Acid SCHEMBL5079597 | 0.77 | NPC1 (0.33) | ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2117251 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL18690028 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL8854007 | 0.74 | KDM4E (0.30) | GAA | |
| Hydrochloric Acid SCHEMBL2389150 | 0.74 | KDM4E (0.30) | GAA | |
| Hydrochloric Acid SCHEMBL2114633 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020736-B1 | ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE PARTICLES AND MOLDED BODY COMPRISING SAME | TOSOH CORP (JP) | 2020-09-09 | — | — | EP | disclosed |
| US-10340492-B2 | Ultrahigh molecular weight polyethylene stretched porous film | TOSOH CORPORATION (JP) | 2019-07-02 | — | — | US | disclosed |
| US-10316119-B2 | Ultrahigh molecular weight polyethylene particles and molded product made thereof | TOSOH CORPORATION (JP) | 2019-06-11 | — | — | US | disclosed |
| US-20170125763-A1 | ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENE STRETCHED POROUS FILM | TOSOH CORPORATION (JP) | 2017-05-04 | — | — | US | disclosed |
| US-20160152744-A1 | ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENE PARTICLES AND MOLDED PRODUCT MADE THEREOF | TOSOH CORPORATION (JP) | 2016-06-02 | — | — | US | disclosed |
| EP-3020736-A1 | ULTRA-HIGH-MOLECULAR-WEIGHT POLYETHYLENE PARTICLES AND MOLDED BODY COMPRISING SAME | Tosoh Corporation (JP) | 2016-05-18 | — | — | EP | disclosed |