Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2389150 | 1.00 | KDM4E (0.30) | KDM4ECYP1A2CYP3A4GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL820215 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL2115084 | 0.86 | POLB (0.33) | CYP1A2CYP3A4GAACYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL7944174 | 0.83 | NPC1 (0.33) | — | |
| Fluoride Ion SCHEMBL7641578 | 0.83 | POLB (0.33) | CYP1A2CYP3A4GAACYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL2138826 | 0.80 | ALDH1A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL822062 | 0.80 | MEN1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6465281 | 0.79 | MEN1 (0.41) | CYP1A2CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL5084084 | 0.79 | MAPT (0.39) | — | |
| Hydrochloric Acid SCHEMBL818671 | 0.76 | SLC25A5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627245-A | Process for the preparation of a syndiotactic propylene copolymer | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | claimed |
| US-5663268-A | Syndiotactic propylene copolymers | HOECHST (DE) | 1997-09-02 | — | — | US | disclosed |
| US-5627245-A | Process for the preparation of a syndiotactic propylene copolymer | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-06 | — | — | US | disclosed |
| US-5232993-A | Homo and copolymerization of propylene in two stages, in the presence of a catalyst having a transition metal component and an organoaluminum compound. | HOECHST AG (DE) | 1993-08-03 | — | — | US | disclosed |