SCHEMBL1774574

SCHEMBL1774574

CC(C)(C)OC(=O)N1CCC(c2nc(CCc3cccc4ccccc34)cs2)CC1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 5/20 0.52
ACHE P22303 1/20 0.47
MAPT P10636 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
F2RL3 Q96RI0 1/20 0.42
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
ACKR3 P25106 1/20 0.40
LMNA P02545 1/20 0.40
FAAH O00519 1/20 0.40
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
NAMPT P43490 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27847342 0.86 GPR119 (0.38) GPR119ACHEKDM4EKMT2A
SCHEMBL1773896 0.85 GPR119 (0.56) GPR119MAPTSMN1; SMN2GAATHRB
SCHEMBL1269808 0.85 GPR119 (0.51) GPR119ACHEMAPTSMN1; SMN2F2RL3
SCHEMBL1773739 0.85 FAAH (0.41) FAAHKDM4EKMT2A
SCHEMBL30926236 0.82 GPR119 (0.58) GPR119MAPTSMN1; SMN2F2RL3GAA
SCHEMBL3144261 0.81 GPR119 (0.60) GPR119MAPTSMN1; SMN2F2RL3GAA
SCHEMBL1118205 0.79 GPR119 (0.72) GPR119SMN1; SMN2F2RL3GAATHRB
SCHEMBL907209 0.79 GPR119 (0.58) GPR119MAPTSMN1; SMN2F2RL3GAA
SCHEMBL1269323 0.79 GPR119 (0.58) GPR119MAPTSMN1; SMN2F2RL3GAA
SCHEMBL17350987 0.78 GRM2 (0.39) MAPTPKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334669-B1 HETEROCYCLYL-SUBSTITUTED THIAZOLES AS PLANT PROTECTION AGENTS BAYER IP GMBH (DE) 2015-12-23 EP disclosed
US-7943774-B2 Heterocyclyl-substituted thiazoles as crop protection agents BAYER CROPSCIENCE AG (DE) 2011-05-17 US disclosed
US-20100137245-A1 Heteerocyclyl-substituted thiazoles as crop protection agents BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137245-A1 Heteerocyclyl-substituted thiazoles as crop protection agents CYP8B1, CYP51A1, HPD GPR119 3388/4885ACHE 3702/4885MAPT 3632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.